Acido solfidrico nella letteratura internazionale

AIMS: Hydrogen sulfide (H2S) is a vasoactive gasotransmitter that is endogenously produced in the vasculature by the enzyme cystathionine gamma-lyase (CSE). However, the importance of CSE activity and local H2S generation for ischemic vascular remodeling remains completely unknown. In this study, we examine the hypothesis that CSE critically regulates ischemic vascular remodeling involving H2S dependent mononuclear cell regulation of arteriogenesis. METHODS AND RESULTS: Arteriogenesis including mature vessel density, collateral formation; blood flow and SPY angiographic blush rate were determined in WT and CSE knockout mice at different time points following femoral artery ligation (FAL). The role of endogenous H2S in regulation of IL-16 expression and subsequent recruitment of monocytes, and expression of VEGF and bFGF in ischemic tissues, were determined along with EPC (CD34/Flk1) formation and function. FAL of wild type mice significantly increased CSE activity, expression and endogenous H2S generation in ischemic tissues and monocyte infiltration, which was absent in CSE deficient mice. Treatment of CSE knockout mice with the polysulfide donor diallyl trisulfide (DATS) restored ischemic vascular remodeling, monocyte infiltration and cytokine expression. Importantly, exogenous H2S therapy restored NO bioavailability in CSEKO mice that was responsible for monocyte recruitment and arteriogenesis. CONCLUSION: Endogenous CSE/H2S regulates ischemic vascular remodeling mediated during hind limb ischemia through NO dependent monocyte recruitment and cytokine induction revealing a previously unknown mechanism of arteriogenesis (24) Sigot L, Ducom G, Benadda B, Laboure C. Comparison of adsorbents for HS and D4 removal for biogas conversion in a solid oxide fuel cell. Environ Technol 2015 Jul 20;1-10. Abstract: Biogas contains trace compounds detrimental for solid oxide fuel cell (SOFC) application, especially sulphur-containing compounds and volatile organic silicon compounds (VOSiCs). It is therefore necessary to remove these impurities from the biogas for fuelling an SOFC. In this paper, dynamic lab-scale adsorption tests were performed on synthetic polluted gas to evaluate the performance of a polishing treatment to remove hydrogen sulphide ( (25) Bradley AS, Leavitt WD, Schmidt M, Knoll AH, Girguis PR, Johnston DT. Patterns of sulfur isotope fractionation during Microbial Sulfate Reduction. Geobiology 2015 Jul 20. Abstract: Studies of microbial sulfate reduction have suggested that the magnitude of sulfur isotope fractionation varies with sulfate concentration. Small apparent sulfur isotope fractionations preserved in Archean rocks have been interpreted as suggesting Archean sulfate concentrations of <200 mum, while larger fractionations thereafter have been interpreted to require higher concentrations. In this work, we demonstrate that fractionation imposed by sulfate reduction can be a function of concentration over a millimolar range, but that nature of this relationship depends on the organism studied. Two sulfate-reducing bacteria grown in continuous culture with sulfate concentrations ranging from 0.1 to 6 mm